該基因編碼一種atp依賴的dna螺旋酶，在核苷酸切除修復中發揮作用。編碼蛋白是基礎轉錄因子2（tfiih）的一個亞單位，因此也在ii類轉錄中起作用。該基因突變與著色性干皮病B、Cockayne綜合征和毛發硫營養不良有關。選擇性剪接導致多個轉錄變體。[由RefSeq提供，2014年12月]
This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]